Question 1

Which of the following thyroid hormones normally peak at 24 to 36 hours post-delivery in a newborn and gradually fall over the first 4 weeks of life?

Accepted Answer

A)  total T₄
B)  fT4
C)  T₃
D)  all of the aboveE) A) and C)
F) A) and D)

Question 2

In primary hyperthyroidism, fT₄ will be ______, and TSH will be _____.

Accepted Answer

A)  increased, decreased
B)  increased, increased
C)  decreased, decreased
D)  decreased, increasedE) A) and B)
F) None of the above

Question 3

There is concern that the upper reference interval value for TSH is set too high to detect subtle hypothyroid disease.It is suggested that the upper reference interval value be reduced to what level to address this concern?

Accepted Answer

A)  5.0 mU/L
B)  4.0 mU/L
C)  3.0 mU/L
D)  2.0 mU/LE) C) and D)
F) B) and D)

Question 4

Which of the following steps in thyroid hormone synthesis, storage, and release are stimulated by TSH?
1) the uptake of amino acids for use in the synthesis of thyroglobulin
2) the uptake of iodine for use in the formation of thyroid hormones
3) the hydrolysis of the thyroglobulin complex to free thyroid hormones
4) thyroid hormone secretion

Accepted Answer

A)  1, 2, 3
B)  1, 2, 4
C)  1, 3, 4
D)  2, 3, 4E) B) and C)
F) C) and D)

Question 5

What tests are used as part of newborn screening programs to identify congenital hypothyroidism?

Accepted Answer

A)  T₃ and/or TSH
B)  T₄ and/or TSH
C)  T₃ and/or T₄
D)  fT₃ and/or T₄E) All of the above
F) B) and C)

Question 6

In patients with developing subclinical hyperthyroidism, TSH levels will likely be ______, and fT₄ will likely be ______.

Accepted Answer

A)  decreased, increased
B)  increased, decreased
C)  decreased, normal
D)  increased, normalE) A) and B)
F) A) and C)

Question 7

Thyroid hormones exert influence in most areas of the body.How do thyroid hormones influence the heart?

Accepted Answer

A)  They affect cardiac gene expression.
B)  They influence the sensitivity of the heart to the sympathetic nervous system.
C)  They cause peripheral hemodynamic alterations that influence cardiac function.
D)  All of the aboveE) A) and C)
F) B) and C)

Question 8

Which of the following characteristics are true of Graves' disease?
1) It is the most common cause of hyperthyroidism.
2) It is more prevalent in men than in women.
3) It is an autoimmune disorder.
4) Patients often have high serum concentration of antibodies against thyroglobulin and thyroid peroxidase.

Accepted Answer

A)  1, 2, 3
B)  1, 2, 4
C)  1, 3, 4
D)  2, 3, 4E) All of the above
F) A) and D)

Question 9

After treatment with medication or radioactive iodine is initiated for hyperthyroidism, disease activity is best initially monitored with ______, because ______ will take several weeks or more to return to the reference interval.

Accepted Answer

A)  TSH, T₄ and T3
B)  TSH, fT₃ and fT₄
C)  fT₃ and fT₄, TSH
D)  serum iodine, TSHE) A) and C)
F) A) and B) C

Question 10

The following laboratory data are suggestive of which clinical situation?
TSH - decreased
T₄ - decreased
T₃ - decreased
RT₃ - increased

Accepted Answer

A)  development of a goiter
B)  euthyroid sick syndrome
C)  Hashimoto's thyroiditis
D)  Graves' diseaseE) A) and D)
F) None of the above

Question 11

Thyroid hormones are metabolized predominantly by deiodination.Which of the following statements are true of deiodinase D1?
1) It is present in high concentration in liver and kidney.
2) It is the main source of T₃ in hyperthyroid patients.
3) It converts T₄ to equimolar amounts of T₃ and rT₃.
4) Its activity is sensitive to changes in serum T₄ and T₃.

Accepted Answer

A)  1, 2, 3
B)  1, 2, 4
C)  1, 3, 4
D)  2, 3, 4E) C) and D)
F) B) and C)

Question 12

Given the following characteristics, which disease state is most likely?
TSH - increased
FT₄ - increased
FT₃ - increased
T₃RU - decreased
TSI - negative
TPO-ab - unlikely to be positive
Thyroid scan uptake - increased

Accepted Answer

A)  Graves' disease
B)  autoimmune thyroiditis
C)  secondary hyperthyroidism
D)  primary hypothyroidismE) B) and C)
F) None of the above

Question 13

During pregnancy, serum TBG concentration ______, total thyroid hormone levels are ______, and free thyroid hormone levels are ______.

Accepted Answer

A)  increases, increased, unaffected
B)  is unaffected, increased, increased
C)  decreases, decreases, unaffected
D)  is unaffected, decreased, decreasedE) A) and D)
F) B) and C)

Question 14

Which amino acid residue of thyroglobulin is responsible for binding iodine in the formation of thyroid hormones?

Accepted Answer

A)  tyrosine
B)  phenylalanine
C)  histidine
D)  guanidineE) A) and B)
F) None of the above A

Question 15

The T₃ resin uptake test is used to measure:

Accepted Answer

A)  total T₃
B)  free T₃
C)  thyroxine binding globulin (TBG) 
D)  TSHE) B) and C)
F) C) and D)

Question 16

Which of the following thyroid hormones is considered to be the most active physiologically?

Accepted Answer

A)  MIT
B)  DIT
C)  T₃
D)  T₄E) None of the above
F) A) and D)

Question 17

Given the following characteristics, which disease state is most likely?
TSH - decreased
FT₄ - increased
FT₃ - increased
T₃RU - increased
TSI - positive
TPO-ab - may be positive
Thyroid scan uptake - uniformly increased

Accepted Answer

A)  Graves' disease
B)  autoimmune thyroiditis
C)  secondary hyperthyroidism
D)  primary hypothyroidismE) C) and D)
F) All of the above A

Question 18

When free thyroxine cannot be measured directly, the free thyroxine index (FT₄I)  may be calculated by using which measured laboratory data?

Accepted Answer

A)  TSH and T₃ resin uptake
B)  T₄ and T₃resin uptake
C)  TSH and T₄
D)  T₃ and T₃resin uptakeE) All of the above
F) B) and C)

Exam 49: Thyroid

Which of the following thyroid hormones normally peak at 24 to 36 hours post-delivery in a newborn and gradually fall over the first 4 weeks of life?

Correct Answer
verified

In primary hyperthyroidism, fT₄ will be __, and TSH will be _.

Correct Answer
verified

There is concern that the upper reference interval value for TSH is set too high to detect subtle hypothyroid disease.It is suggested that the upper reference interval value be reduced to what level to address this concern?

Correct Answer
verified

Correct Answer
verified

What tests are used as part of newborn screening programs to identify congenital hypothyroidism?

Correct Answer
verified

In patients with developing subclinical hyperthyroidism, TSH levels will likely be , and fT₄ will likely be .

Correct Answer
verified

Thyroid hormones exert influence in most areas of the body.How do thyroid hormones influence the heart?

Correct Answer
verified

Correct Answer
verified

After treatment with medication or radioactive iodine is initiated for hyperthyroidism, disease activity is best initially monitored with , because will take several weeks or more to return to the reference interval.

Correct Answer
verified
C

The following laboratory data are suggestive of which clinical situation? TSH - decreased T₄ - decreased T₃ - decreased RT₃ - increased

Correct Answer
verified

Correct Answer
verified

Given the following characteristics, which disease state is most likely? TSH - increased FT₄ - increased FT₃ - increased T₃RU - decreased TSI - negative TPO-ab - unlikely to be positive Thyroid scan uptake - increased

Correct Answer
verified

During pregnancy, serum TBG concentration , total thyroid hormone levels are , and free thyroid hormone levels are __.

Correct Answer
verified

Which amino acid residue of thyroglobulin is responsible for binding iodine in the formation of thyroid hormones?

Correct Answer
verified
A

The T₃ resin uptake test is used to measure:

Correct Answer
verified

Which of the following thyroid hormones is considered to be the most active physiologically?

Correct Answer
verified

Given the following characteristics, which disease state is most likely? TSH - decreased FT₄ - increased FT₃ - increased T₃RU - increased TSI - positive TPO-ab - may be positive Thyroid scan uptake - uniformly increased

Correct Answer
verified
A

When free thyroxine cannot be measured directly, the free thyroxine index (FT₄I) may be calculated by using which measured laboratory data?

Correct Answer
verified

Exam 49: Thyroid

Which of the following thyroid hormones normally peak at 24 to 36 hours post-delivery in a newborn and gradually fall over the first 4 weeks of life?

Correct AnswerverifiedShow Answer

In primary hyperthyroidism, fT₄ will be ______, and TSH will be _____.

Correct AnswerverifiedShow Answer

There is concern that the upper reference interval value for TSH is set too high to detect subtle hypothyroid disease.It is suggested that the upper reference interval value be reduced to what level to address this concern?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

What tests are used as part of newborn screening programs to identify congenital hypothyroidism?

Correct AnswerverifiedShow Answer

In patients with developing subclinical hyperthyroidism, TSH levels will likely be ______, and fT₄ will likely be ______.

Correct AnswerverifiedShow Answer

Thyroid hormones exert influence in most areas of the body.How do thyroid hormones influence the heart?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

After treatment with medication or radioactive iodine is initiated for hyperthyroidism, disease activity is best initially monitored with ______, because ______ will take several weeks or more to return to the reference interval.

Correct AnswerverifiedC

The following laboratory data are suggestive of which clinical situation? TSH - decreased T₄ - decreased T₃ - decreased RT₃ - increased

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Given the following characteristics, which disease state is most likely? TSH - increased FT₄ - increased FT₃ - increased T₃RU - decreased TSI - negative TPO-ab - unlikely to be positive Thyroid scan uptake - increased

Correct AnswerverifiedShow Answer

During pregnancy, serum TBG concentration ______, total thyroid hormone levels are ______, and free thyroid hormone levels are ______.

Correct AnswerverifiedShow Answer

Which amino acid residue of thyroglobulin is responsible for binding iodine in the formation of thyroid hormones?

Correct AnswerverifiedA

The T₃ resin uptake test is used to measure:

Correct AnswerverifiedShow Answer

Which of the following thyroid hormones is considered to be the most active physiologically?

Correct AnswerverifiedShow Answer

Given the following characteristics, which disease state is most likely? TSH - decreased FT₄ - increased FT₃ - increased T₃RU - increased TSI - positive TPO-ab - may be positive Thyroid scan uptake - uniformly increased

Correct AnswerverifiedA

When free thyroxine cannot be measured directly, the free thyroxine index (FT₄I) may be calculated by using which measured laboratory data?

Correct AnswerverifiedShow Answer

Correct Answer
verified

In primary hyperthyroidism, fT₄ will be __, and TSH will be _.

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

In patients with developing subclinical hyperthyroidism, TSH levels will likely be , and fT₄ will likely be .

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

After treatment with medication or radioactive iodine is initiated for hyperthyroidism, disease activity is best initially monitored with , because will take several weeks or more to return to the reference interval.

Correct Answer
verified
C

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

During pregnancy, serum TBG concentration , total thyroid hormone levels are , and free thyroid hormone levels are __.

Correct Answer
verified

Correct Answer
verified
A

Correct Answer
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Correct Answer
verified

Correct Answer
verified
A

Correct Answer
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